Abstract Sickle Cell Disease (SCD) is a severe hereditary blood disorder that affects millions worldwide, primarily individuals of African, Mediterranean, Middle Eastern, and Indian descent. The disease is characterised by the presence of abnormal haemoglobin S, leading to sickling of red blood cells (RBCs), vaso-occlusive crises (VOCs), and organ damage. Historically, treatment options have been […]
Tag Archives: Sickle cell amemia
Abstract Pain in Sickle Cell Disease (SCD) is one of the most debilitating symptoms, often leading to acute and chronic suffering. This paper explores the neurophysiological pathways involved in the initiation and transmission of pain in SCD, highlighting the root causes, such as nerve fibres, pain sensors, and their interactions. The paper further investigates the […]
