Abstract Methemoglobinemia is a pathological condition characterised by the oxidation of haemoglobin’s ferrous iron (Fe²⁺) to ferric iron (Fe³⁺), impairing its ability to transport oxygen. In sickle cell disease (SCD) and other disorders, oxidative stress and redox imbalances promote excessive methemoglobin (MetHb) formation, worsening hypoxia and tissue damage. This paper explores the biochemical mechanisms driving […]
Tag Archives: Nitrite
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The Role of Nitrate and Nitrite in Regulating Atomic and Molecular Spin for Cellular Balance and the Management of Sickle Cell Disease
Abstract The regulation of atomic and molecular spin at the cellular level plays a fundamental role in maintaining biological harmony. In the context of sickle cell disease (SCD), abnormal haemoglobin polymerisation leads to the characteristic sickling of red blood cells, impairing oxygen delivery and causing systemic complications. This paper explores how nitrate (NO₃⁻) and nitrite […]
